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. 2015 Oct 19;6(42):44179–44190. doi: 10.18632/oncotarget.6175

Table 1. The functional classification of exosomal proteins.

Biological function Exosomal protein Reference
Exosome biogenesis ESCRT(I,II,III), Alix, TSG(10,101), GAG [22-24]
Cytoskeleton organization Actin, Adivillin, CAP1, Confilin, Moesin, Radixin, Talin, Tubulin [25]
Tetraspanins (membrane protein organization) CD9, CD37, CD53, CD63, CD81, CD82 [26, 27]
Transport and fusion Annexins (I,II,IV,V,VI), RABGDI, RAP1B, RAB(5,7,11,27,35), Flotillin [7, 21, 28-30]
Targeting/adhesion Integrins(α4β1,αMβ2,αLβ2,β2), CD11(a, b, c), MFG-E8/lactadherin, CD166,LFA-3/CD58, CD18, CD9, ALCAM, ICAM-1 [21, 28, 31]
Antigen presentation MHC (I, II), CD86, HSC70, HSP84/90 [7, 32, 33]
Signal transduction Gi2α/14-3-3, Gi3α, ERK2, FRL, Catenin, Fyn, Rho(A,C), GDI, Syntenin, G proteins [25, 31]
Anti-apoptosis Thioredoxine peroxidase, Alix, Galectin 3 [21]
Protection from lysis CD55, CD59 [34]
Metabolic enzymes ATP citrate lyase, ATPase, Thioredoxine peroxidase, Aldehyde reductase, Pyruvate kinase, GAPDH, AChE, Aspartate amino transferase, Fatty acid synthase, Glucose 6 phosphate isomerase [7, 27]