Figure 6. Cx43-hUCSC transplantation increases survival time of mice with minimal residual disease (MRD).

L615 mouse MRD model were generated by injection of L615 leukemia cells into L615 mouse followed with chemotherapy (CTX, 200 mg/kg). Two weeks of CTX treatment reduce the L615 cell to an undetectable level. Transplantations with Cx43-hUCSC (1 × 10⁶) mixed with BM (1 × 10⁶) or BM alone (2 × 10⁶) were performed via tail vein two weeks post CTX treatment. Mortality rate of injected mice was monitored for 30 days after the injections and was calculated to be 15% lower in mice transplanted with Cx43-hUCSC than that with BM alone. The average survival time of mice injected with Cx43-hUCSC (27 days after transplant) is significantly longer than that of the BM group (23 days).