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. 2015 Oct 26;6(42):44466–44479. doi: 10.18632/oncotarget.6298

Figure 7. YAP/TAZ activation is essential for miR-181c-induced chemoresistance.

Figure 7

A. TEAD transcriptional activity was increased by MST1 or LATS2 depletion in the cells. (B and C) TUNEL B. and colony formation assays C. indicating that silencing of MST1 or LATS2 promoted pancreatic cancer cell chemoresistance and survival. D. TEAD transcriptional activity induced by miR-181c was suppressed by YAP or TAZ depletion in the cells. (E and F) TUNEL E. and colony formation assays F. indicating that YAP or TAZ silencing abrogated miR-181c–induced promotion of pancreatic cancer cell chemoresistance and survival. Error bars represent the mean ± s.d. of three independent experiments. *P < 0.05.