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. 2015 Oct 27;6(42):44538–44550. doi: 10.18632/oncotarget.6253

Figure 7. The miR-222-ABCG2 pathway regulates xenograft growth and lung metastasis of TSCC in vivo.

Figure 7

A. CAL27 cells stably infected with control siRNA or ABCG2 siRNA were inoculated subcutaneously into nude mice. Xenografts were measured every 3 days with a caliper, and growth curves demonstrated that ABCG2 knockdown significantly inhibited CAL27 xenograft growth. B. CAL27 cells stably infected with control mimics or miR-222 mimics were inoculated subcutaneously into nude mice. Growth curves demonstrated that miR-222 mimics significantly inhibited CAL27xenograft growth. C. UM1 cells stablyinfected with control siRNA or ABCG2 siRNA were injected into the tail vein of nude mice. Metastatic TSCC in the lung was assessed at week 6 after injection, as described in the methods. The histopathological analysis of lung metastasis (magnification 400×) and nodules of lung metastasis are shown. D. UM1 cells stably infected with control mimics or miR-222 mimics were injected into the tail vein of nude mice. The histopathological analysis of lung metastasis (magnification 400×) and nodules of lung metastasis are shown. *p < 0.05.