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. 2015 Nov 9;6(42):44635–44642. doi: 10.18632/oncotarget.5988

Figure 5. PPARα/Bcl2 signaling promotes cell apoptosis in response to chemotherapy drugs.

Figure 5

A. PPARα shRNA silenced SW480 cells were treated with chemotherapy drugs (camptothecin, taxol, etoposide, cisplatinum) as indicated for 24 h. Cell viability was assayed (see experimental procedures). Results are expressed as means ± SEM (n = 3). B. SW480 cells were transiently transfected with vector, PPARα, C102A plasmids as indicated. Cells were treated with chemotherapy drugs (camptothecin, taxol, etoposide, cisplatinum) for 24 h. Cell viability was assayed (see experimental procedures). Results are expressed as means ± SEM (n = 3). C. SW480 cells were transiently transfected plasmids as indicated. Cells were treated with camptothecin (60 μM), taxol (300 μM), etoposide (600 μM), and cisplatinum (30 μM) for 6 h. Cell lysates were subjected to Western blot. D. SW480 cells were transfected with control or PPARα shRNA as indicated. Cells were treated without or with etoposide for 24 h. Cell apoptosis was assayed (see experimental procedures).