Table 4. Significant KEGG gene set enriched in patients with clinical benefit to dacomitinib.

	Gene set	Size	ES	NES	Nominal p value	FDR q value	Rank at Max
1	KEGG_JAK_STAT_SIGNLING_PATHWAY	19	0.71	2.07	0.000	0.000	37
2	KEGG_APOPTOSIS	17	0.68	2.04	0.000	0.000	24
3	KEGG_NEUROTROPHIN_PATHWAY	19	0.67	1.99	0.000	0.000	19
4	KEGG_ENDOCYTOSIS	17	0.75	1.90	0.000	0.002	41
5	KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	30	0.65	1.90	0.001	0.002	41
6	KEGG_ERBB_SIGNALING_PATHWAY	20	0.63	1.88	0.000	0.002	42
7	KEGG_T-CELL_RECEPTOR_SIGNLING_PATHWAY	15	0.61	1.87	0.000	0.002	33
8	KEGG_REGULATION_OF_ACTIN_CYTOSKELETON	20	0.59	1.83	0.001	0.003	40
9	KEGG_PATHWAYS_IN_CANCER	85	0.49	1.81	0.000	0.004	57
10	KEGG_MELANOMA	29	0.52	1.78	0.000	0.005	49
11	KEGG_PROSTATE_CANCER	31	0.50	1.78	0.000	0.005	69
12	KEGG_GLIOMA	25	0.51	1.78	0.000	0.004	49
13	KEGG_CELL_CYCLE	28	0.51	1.76	0.002	0.006	69
14	KEGG_ACUTE _MYELOID_LEUKEMIA	18	0.51	1.70	0.005	0.010	26
15	KEGG_PANCREATIC_CANCER	25	0.49	1.68	0.001	0.011	49
16	KEGG_P53 _SIGNALING_PATHWAY	20	0.51	1.67	0.001	0.012	77
17	KEGG_MAPK_SIGNALING_PATHWAY	36	0.52	1.67	0.005	0.012	42
18	KEGG_NON_SMALL_CELL_LUNG_CANCER	20	0.51	1.63	0.008	0.019	49
19	KEGG_FOCAL_ADHESION	31	0.50	1.60	0.037	0.023	62
20	KEGG_ENDOMETRIAL_CANCER	19	0.50	1.59	0.012	0.024	40

KEGG, Kyoto Encyclopedia of Genes and Genomes; ES, Enrichment score; NES, Normalized enrichment score