Table 3. Factors associated with interventions in the overall population.

	Univariable Analysis				Multivariable Analysis
	Palliative Chemotherapy vs. Best Supportive Care (OR 95%CI)	p-value	Surgery vs. Best Supportive Care (OR (95%CI)	p-value	Palliative Chemotherapy vs. Best Supportive Care (OR 95%CI)	p-value	Surgery vs. Best Supportive Care (OR 95%CI)	p-value
Age, ≥70 years	0.39 (0.27–0.56)	< .0001	0.63 (0.46–0.87)	0.004	0.35 (0.35–0.75)	0.0007	0.70 (0.48–1.04)	0.07
Gender, Female	0.71 (0.51–0.99)	0.04	0.64 (0.47–0.88)	0.006	0.69 (0.48–0.99)	0.046	0.71 (0.49–1.03)	0.07
Site, Gallbladder	0.62 (0.44–0.87)	0.006	0.55 (0.40–0.77)	0.0004	0.55 (0.38–0.81)	0.002	0.79 (0.53–1.17)	0.25
CCI	0.87 (0.76–0.99)	0.03	1.00 (0.91–1.09)	0.95	0.90 (0.78–1.02)	0.10	1.04 (0.94–1.16)	0.42
Stage I / Stage II	0.31 (0.19–0.51)	< .0001	5.97 (4.20–8.49)	< .0001	0.31 (0.18–0.53)	< .0001	6.08 (4.10–9.03)	< .0001
ECOG, ≥2	0.30 (0.18–0.51)	< .0001	0.09 (0.04–0.19)	< .0001	0.37 (0.22–0.65)	0.0005	0.09 (0.04–0.20)	< .0001

Abbreviations: ECOG PS: European Cooperative Oncology Group Performance Status; CCI: Charlson Co-morbidity index