Table 4. Univariable and multivariable survival analysis by age group.

	Patients <70 years old				Patients ≥70 years old
	Univariable		Multivariable		Univariable		Multivariable
	HR (95%CI)	p-value	HR (95%CI)	p-value	HR (95%CI)	p-value	HR (95%CI)	p-value
Gender, Female	1.01 (0.89–1.32)	0.41			0.95 (0.74–1.23)	0.72
Site, Gallbladder	1.37 (1.12–1.68)	0.003	1.10 (0.97–1.48)	0.10	1.03 (0.79–1.34)	0.81
CCI	0.96 (0.88–1.05)	0.36			0.98 (0.92–1.05)	0.62
Stage I / Stage II	0.34 (0.29–0.43)	< .0001	0.55 (0.42–0.71)	< .0001	0.40 (0.30–0.53)	< .0001	0.39 (0.29–0.54)	< .0001
ECOG, ≥2	2.90 (2.00–4.22)	< .0001	2.45 (1.67–3.59)	< .0001	2.78 (2.03–3.81)	< .0001	2.05 (1.48–3.84)	< .0001
Treatment								< .0001
Surgery	0.16 (0.13–0.21)	< .0001	0.20 (0.15–0.27)	< .0001	0.27 (0.20–0.37)	< .0001	0.29 (0.21–0.41)	< .0001
Palliative chemotherapy	0.49 (0.39–0.62)	< .0001	0.44 (0.34–0.56)	< .0001	0.72 (0.53–0.99)	0.04	0.50 (0.36–0.71)	< .0001
Best supportive care	−		−		−		−

Abbreviations: ECOG PS: European Cooperative Oncology Group Performance Status; CCI: Charlson Co-morbidity index