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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Shock. 2016 Apr;45(4):338–348. doi: 10.1097/SHK.0000000000000513

Figure 2. Structure of Syndecans and glypicans.

Figure 2

The generalized structure of syndecan 1-4 (left panel) and glypicans 1-6 (right panel) are shown for comparison. The primary structural features to note are that syndecans have a transmembrane region and a highly conserved cytoplasm domain that participates in signaling. Syndecan can carry both heparan sulfate GAGs and chondroitin sulfate GAG. Glypicans contain a larger core protein, insert into the membrane via a GPI anchor and only carry heparan sulfate GAGs. Modified from: CE. Bandtlow and Dieter R. Zimmermann Physiol Rev 2000;80:1267-1290