Table 3.
Top 5 CpGs pyrosequenced in an independent set of 6 disease-discordant MZ twin pairs
| TargetID | UCSC REFGENE Name | Fraction Hypermethylated in Affected Twin | Wilcoxon Signed-Rank P-value | Average- Beta Difference | Mean (cases) | Mean (controls) |
|---|---|---|---|---|---|---|
| MHC region genes | ||||||
| cg18501647 | PRRT1 | 66.7% | 0.438 | 0.027 | 0.792 | 0.766 |
| Non-MHC, T1D-associated Genes | ||||||
| cg16413785 | C14orf64 | 50.0% | 0.563 | 0.051 | 0.509 | 0.458 |
| cg09818385 | BACH2;BACH2 | 33.3% | 0.844 | 0.003 | 0.575 | 0.572 |
| cg26316423 | IL2RA;IL2RA | 83.3% | 0.219 | 0.044 | 0.756 | 0.713 |
| Epigenome | ||||||
| cg25340050 | PCDHB16 | 33.3% | 0.563 | −0.032 | 0.348 | 0.380 |
Average-Beta (DNAm) differences were calculated as affected-unaffected; a positive number indicates that a greater methylation percentage was observed in the affected individual.