Table 1. Baseline Characteristics of Study Participants and Sample Submission Rates.
Description of study participant characteristics reported in percentages, with the exception of Charlson Comorbidity Index Score which is reported as mean. Submission rates of stool and serum samples, including initial enrollment and 12-month observation period, also reported.
| IBD | Control | Total | p-value* | ||||
|---|---|---|---|---|---|---|---|
| CD | UC | IPAA | IBD Group | ||||
| 50 | 45 | 23 | 118 | 28 | 146 | ||
| Age (years) | 41.8 +/− 15.1 | 38.6 +/− 14.3 | 48.9 +/− 14.5 | 42.0 +/− 15.0 | 45.6 +/−15.6 | 42.7 +/−15.1 | 0.0382 |
| Male | 36.0% | 51.1% | 34.8% | 41.5% | 50.0% | 43.2% | 0.3344 |
| Shelter or Nursing home resident | 4.0% | 0.0% | 0.0% | 1.7% | 7.1% | 2.7% | 0.2852 |
| Current tobacco use | 18.0% | 4.4% | 17.4% | 12.7% | 35.7% | 17.1% | 0.0056 |
| Tobacco use ever | 32.0% | 24.4% | 39.1% | 30.5% | 42.9% | 32.9% | 0.3707 |
| CDI in the past 1 month | 8.0% | 8.9% | 4.4% | 7.6% | 7.1% | 7.5% | 0.9714 |
| Flare or diarrhea at time of enrollment | 72.0% | 82.2% | 78.3% | 77.1% | 53.9% | 72.9% | 0.0683 |
| Abdominal pain | 32.0% | 35.6% | 34.8% | 33.9% | 60.7% | 39.0% | 0.0728 |
| Hospitalizations in the past 6 months | 30.0% | 2.2% | 8.7% | 15.3% | 29.6% | 17.9% | 0.0003 |
| Antibiotic use in the past 6 months | 32.0% | 33.3% | 47.8% | 35.6% | 50.0% | 38.4% | 0.2824 |
| PPI use in the past 6 months | 24.0% | 20.0% | 13.0% | 20.3% | 42.9% | 24.7% | 0.0658 |
| 5-ASA use in the past 6 months | 42.0% | 73.3% | 8.7% | 47.5% | 0.0% | 38.6% | <.0001 |
| Immunomodulator use in the past 6 months | 38.0% | 26.7% | 17.4% | 29.7% | 0.0% | 24.1% | 0.0022 |
| Anti-TNF use in the past 6 months | 22.0% | 17.8% | 4.4% | 16.9% | 0.0% | 13.8% | 0.0130 |
| Charlson Comorbidity Index Score (mean) | 1.5 +/− 1.1 | 1.5 +/− 0.8 | 0.9 +/− 1.1 | 1.4 +/− 1.0 | 0.8 +/− 1.0 | 1.3 +/− 1.0 | 0.0016 |
| Submitted blood samples | 88.0% | 66.7% | 91.3% | 80.5% | 78.6% | 80.1% | |
| Submitted stool samples | 84.0% | 75.6 | 95.7% | 83.1% | 75.0% | 81.5% | |
| # c. difficile infection | 12.0% | 6.7% | 4.3% | 8.5% | 10.7% | 8.9% | 0.7475 |
| # c. difficile colonization | 2.0% | 2.2% | 0% | 1.7% | 0% | 1.4% | |
| # NAP1/027 hypervirulent strain | 0% | 0% | 0% | 0% | 0% | 0% | |
| Submitted both blood and stool samples | 72.0% | 42.2% | 82.6% | 62.7% | 53.6% | 6.0% | |
*
Based on ANOVA for continuous variables and Chi-Square or Fisher’s Exact Test for categorical predictors, as appropriate.