Table 2.

Breast cancer first events NSABP Protocol B-35

	Number of Events		Hazard Ratio (HR)	95% Confidence Interval	P-value
	Tamoxifen (n=1,538)	Anastrozole (n=1,539)
All breast cancers
Total	122	90	0.73	(0.56 – 0.96)	0.0234
Invasive	69	43	0.62	(0.42 – 0.90)	0.0123
Ductal carcinoma in situ	53	47	0.88	(0.59 – 1.30)	0.52
Ipsilateral recurrence
Total	55	46	0.83	(0.56 – 1.22)	0.34
Invasive	22	17	0.76	(0.40 – 1.43)	0.39
Ductal carcinoma in situ	33	29	0.87	(0.53 – 1.43)	0.59
Contralateral breast cancer
Total	60	39	0.64	(0.43 – 0.96)	0.0322
Invasive	40	21	0.52	(0.31 – 0.88)	0.0148
Ductal carcinoma in situ	20	18	0.90	(0.47 – 1.69)	0.73
Breast cancer at distant sites	7	4	0.57	(0.17 – 1.95)	0.37
Breast second primary cancer*	0	1	–	–	–

^*Angiosarcoma in the ipsilateral breast