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. Author manuscript; available in PMC: 2017 Feb 18.
Published in final edited form as: Cell Chem Biol. 2016 Feb 4;23(2):225–235. doi: 10.1016/j.chembiol.2015.11.016

Figure 2. Scheme of the NCI-60 pharmacogenomic analysis.

Figure 2

(i) Drug sensitivity data were filtered using the ‘cell-line selectivity’ metric, followed by model-based clustering and consolidation of clustering into 18 clusters. (ii) 13,748 genes with larger dispersion in expression were selected based on IQR of their expression across the NCI-60 cell line panel. (iii) The Spearman correlation coefficient between drug sensitivity of each lethal compound cluster and the transcriptional profile of each gene across the NCI-60 panel was computed. (iv) The correlation coefficients between compound clusters and genes were used to compute GO enrichment analysis for each compound cluster.