Table 1.
Model name | Mutation | Hyperphagia | Hyperglycemia | Insulin Resistance |
---|---|---|---|---|
MONOGENIC MUTATIONS IN THE LEPTIN PATHWAY | ||||
ob/ob mouse | Lepob/Lepob(leptin deficiency) |
+ | +/− | + |
db/db mouse | Lepdb/Lepdb(leptin receptor) |
+ | + | + |
Zucker rat | mutated leptin receptor (fa/fa) |
+ | +/− | + |
ZDF rat | mutated leptin receptor (fa/fa) |
+ | + | + |
POMC knockout mouse |
POMC deficiency | + | +/− | + |
POMC/AgRP double knockout mice |
POMC and AgRP deficiency |
+ | +/− | + |
MC4R knockout mouse |
melanocortin 4 receptor |
+ | +/− | + |
MC4R knockout rat | melanocortin 4 receptor |
+ | +/− | + |
MC4/MC3 receptor double knockout mouse |
+ | +/− | + | |
DIET-INDUCED MODELS; POLYGENIC MODELS | ||||
Diet-induced obese (DIO) rat |
Polygenic | + | +/− | + |
Cafeteria diet induced obesity |
Polygenic | + | +/− | + |
High-fat diet-induced obesity |
Polygenic | + | +/− | + |
New Zealand obese mouse |
Polygenic | + | + | + |