Table 1.
Summary of commonly used animal models of obesity
| Model name | Mutation | Hyperphagia | Hyperglycemia | Insulin Resistance |
|---|---|---|---|---|
| MONOGENIC MUTATIONS IN THE LEPTIN PATHWAY | ||||
| ob/ob mouse | Lepob/Lepob(leptin deficiency) |
+ | +/− | + |
| db/db mouse | Lepdb/Lepdb(leptin receptor) |
+ | + | + |
| Zucker rat | mutated leptin receptor (fa/fa) |
+ | +/− | + |
| ZDF rat | mutated leptin receptor (fa/fa) |
+ | + | + |
| POMC knockout mouse |
POMC deficiency | + | +/− | + |
| POMC/AgRP double knockout mice |
POMC and AgRP deficiency |
+ | +/− | + |
| MC4R knockout mouse |
melanocortin 4 receptor |
+ | +/− | + |
| MC4R knockout rat | melanocortin 4 receptor |
+ | +/− | + |
| MC4/MC3 receptor double knockout mouse |
+ | +/− | + | |
| DIET-INDUCED MODELS; POLYGENIC MODELS | ||||
| Diet-induced obese (DIO) rat |
Polygenic | + | +/− | + |
| Cafeteria diet induced obesity |
Polygenic | + | +/− | + |
| High-fat diet-induced obesity |
Polygenic | + | +/− | + |
| New Zealand obese mouse |
Polygenic | + | + | + |