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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Environ Mol Mutagen. 2016 Jan 13;57(3):171–189. doi: 10.1002/em.21996

Figure 13.

Figure 13

Fold-increases in polyploidy cells are graphed for each of the test set chemicals for the 24 hr time point. Chemicals are coded according to genotoxic MoA: clastogens = red circles, aneugens = blue squares, and non-genotoxicants = green triangles. A series of data points are plotted for each chemical, as each represents a different concentration. These data show chemicals’ polyploidization responses, with aneugens showing the greatest effects. Note that in the case of 2-acetylaminofluorene, 7,12-dimethylbenzanthracene, benzo[a]pyrene, and cyclophosphamide, TK6 cells were exposed to test article in the presence of a rat liver S9 activation system, and after 4 hrs were washed with fresh growth medium.