Figure 8.

Multinomial logistic regression probabilities for an aneugen classification are graphed for each of 67 training set chemicals. Chemicals are coded according to genotoxic MoA: clastogens = red circles, aneugens = blue squares, and non-genotoxicants = green triangles. A series of probabilities are plotted for each chemical, as each represents a different concentration. These data show that each of the aneugens were correctly classified by the four-factor model (two successive concentrations with probabilities in excess of 0.90, i.e., 90%), while none of the clastogens or non-genotoxicants were misclassified as aneugens.