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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: Clin Pharmacokinet. 2016 Apr;55(4):495–506. doi: 10.1007/s40262-015-0332-9

Figure 2. Mean nizatidine plasma concentrations following administration of a single oral dose to 12 healthy volunteers.

Figure 2

Nizatidine plasma concentrations were determined after a 600 mg single oral dose in combination with metformin. The dotted horizontal lines are drawn at Cfu/IC50 ratios of 1, 0.1 (FDA cut-off) and 0.02 (EMA cut-off). Data represent mean ± SEM.

Cfu, unbound concentration in plasma; IC50, concentration at half the maximum inhibition of active transport; FDA, Food and Drug Administration; EMA, European Medicines Agency