Table 2.
In-situ hybridization and immunohistochemical findings in HPV-related large cell neuroendocrine carcinomas of the head and neck
| Case # | CK | p63 | CK5/6 | synaptophysin | chromogranin | TTF-1 | CD56 | p16 | HPV ISH* |
|---|---|---|---|---|---|---|---|---|---|
| 1 | + | − | − | + | − | − | + | + | + |
| 2 | + | − | − | + | − | − | − | + | + |
| 3 | + | − | + | + | + | − | ND | + | + |
| 4 | + | − | − | focal + | − | − | + | − | ND |
| 5 | + | +(in SqCC) | + (in SqCC) | + | + | − | focal + | − | ND |
| 6 | + | + (in SqCC) | +(in SqCC) | − | − | − | + | + | − |
| 7 | + | − | − | + | − | − | − | + | − |
| 8 | + | focal + | ND | + | − | − | + | − | ND |
| 9 | + | focal + | − | + | − | − | − | − | − |
| 10 | + | − | ND | + | + | − | ND | + | − |
Abbreviations: HPV = human papillomavirus; CK = cytokeratin; SqCC = squamous cell carcinoma; TTF-1 = thyroid transcription factor-1; ISH = in situ-hybridization; ND = not done; focal = immunostaining in ≤5% of cells.