Table 1.
Minimum inhibitory concentrations (MICs) of auranofin and control antibiotics against Staphylococcus aureus and Staphylococcus epidermidis
| Strain type | Strain ID | Source | Phenotypic properties | MIC (μg/mL) |
||
|---|---|---|---|---|---|---|
| Auranofin | Linezolid | Vancomycin | ||||
| Meticillin-sensitive S. aureus (MSSA) | ATCC 6538 | Quality control and biofilm-forming strain | 0.0625 | 2 | 1 | |
| Meticillin-resistant S. aureus (MRSA) | RN4220 | USA | Resistant to penicillin | 0.0625 | 2 | 1 |
| NRS72 | UK | 0.125 | 2 | 1 | ||
| NRS77 | UK | 0.0625 | 2 | 1 | ||
| NRS846 | – | 0.0625 | 2 | 1 | ||
| NRS860 | – | 0.125 | 2 | 1 | ||
| USA300 | USA (Mississippi) | Resistant to erythromycin, meticillin and tetracycline | 0.125 | 2 | 1 | |
| NRS194 | USA (North Dakota) | Resistant to meticillin | 0.0625 | 2 | 1 | |
| NRS108 | France | Resistant to gentamicin | 0.125 | 2 | 1 | |
| NRS119 (Linr) | USA (Massachusetts) | Resistant to linezolid | 0.0625 | >16 | 1 | |
| ATCC 43300 | USA (Kansas) | Resistant to meticillin | 0.0625 | 2 | 1 | |
| ATCC BAA-44 | Lisbon, Portugal | Multidrug-resistant strain | 0.0625 | 2 | 1 | |
| NRS70 | Japan | Resistant to erythromycin, clindamycin and spectinomycin | 0.0625 | 2 | 1 | |
| NRS71 | UK | Resistant to tetracycline and meticillin | 0.0625 | 2 | 1 | |
| NRS100 | USA | Resistant to tetracycline and meticillin | 0.0625 | 2 | 1 | |
| NRS123 | USA (North Dakota) | Resistant to tetracycline and meticillin | 0.0625 | 2 | 2 | |
| NRS107 | – | Resistant to meticillin and mupirocin | 0.0625 | 2 | 1 | |
| Vancomycin-intermediate S. aureus (VISA) | NRS1 | Japan | Resistant to aminoglycosides and tetracycline; glycopeptide-intermediate S. aureus | 0.0625 | 2 | 8 |
| NRS19 | USA (Illinois) | Glycopeptide-intermediate S. aureus | 0.125 | 1 | 2 | |
| NRS37 | France | Glycopeptide-intermediate S. aureus | 0.125 | 1 | 4 | |
| Vancomycin-resistant S. aureus (VRSA) | VRS1 | USA | Resistant to vancomycin | 0.0625 | 1 | >16 |
| VRS2 | USA | Resistant to vancomycin, erythromycin and spectinomycin | 0.0625 | 1 | 8 | |
| VRS3a | USA | Resistant to vancomycin | 0.0625 | 2 | >16 | |
| VRS3b | USA | Resistant to vancomycin | 0.0625 | 2 | >16 | |
| VRS4 | USA | Resistant to vancomycin, erythromycin and spectinomycin | 0.0625 | 2 | >16 | |
| VRS5 | USA | Resistant to vancomycin | 0.0625 | 2 | >16 | |
| VRS6 | USA | Resistant to vancomycin | 0.125 | 2 | >16 | |
| VRS7 | USA | Resistant to vancomycin and β-lactams | 0.0625 | 2 | >16 | |
| VRS8 | USA | Resistant to vancomycin | 0.0625 | 2 | >16 | |
| VRS9 | USA | Resistant to vancomycin | 0.0625 | 2 | >16 | |
| VRS10 | USA | Resistant to vancomycin | 0.125 | 2 | >16 | |
| VRS11a | USA | Resistant to vancomycin | 0.0625 | 2 | >16 | |
| VRS11b | USA | Resistant to vancomycin | 0.0625 | 2 | >16 | |
| VRS12 | USA | Resistant to vancomycin | 0.125 | 2 | >16 | |
| VRS13 | USA | Resistant to vancomycin | 0.0625 | 2 | >16 | |
| S. epidermidis | NRS101 | USA | Prototype biofilm-producer; resistant to meticillin and gentamicin | 0.0625 | 2 | 1 |