Fig. 3.

Hyperpolarizing and depolarizing input pulses have differential preferred input phases that induce spiking. (a) Control current inputs used are shown in the first column. These include (a1) standard, (a2) normalized, (a3) random, (a4) sparse, and (a5) depolarizing current inputs, respectively. (b–d) Rose plots show phase histograms for hyperpolarizing (a1–a4) or depolarizing (a5) input pulses that induce subsequent spiking (b1–b5) and for the phase of output spiking (c1–c5) for the entire population (n = 72) of cells. Rose plots correspond to a given input with matching numerical labels in each row. (d and e) Bar graphs show input (d) and output (e) MRLs do not differ between hyperpolarizing inputs, but are significantly larger than the response to depolarizing inputs in terms of both input and output MRLs (paired t-test, *p < 0.05; ***p < 0.001). (f and g) Bar graphs show input MRAs (f) do not differ between different patterns of hyperpolarizing input pulses, but are significantly larger than depolarizing inputs (paired t-test, ***p < 0.001), while all output MRAs are similar (g). Abbreviations in d–g are as follow: Stand = standard input, Norm = normalized input, Rand = random input, Spar = Sparse input, and Depol = depolarizing input.