Table 2.
Primary information on the analyzed polymorphisms
| GENE | SNP | LOCATION | SNP FUNCTION/ASSOCIATION | F-SNP SCORE |
|---|---|---|---|---|
| MST1 | rs17420378 | Exon 11 | Missense Val312Met |
0.533 |
| rs6073629 | 3′UTR | Transcriptional regulation | 0.5 | |
| MST2 | rs10955176 | 3′UTR | NA | NFI |
| LATS1 | rs12174349 | 5′UTR | NA | NFI |
| LATS2 | rs558614 | Exon 4 | Missense Ala324Aval |
0.156 |
| LATS2 | rs9552315 | 3′UTR | Transcriptional regulation | 0.5 |
| YAP | rs8504 | 3′UTR | NA | NFI |
| rs1820453 | Upstream | Survival in NSCLC27 | NFI | |
| TAZ | rs3811715 | Intron | Splice donor | 0.242 |
| rs6783790 | Intron | Splice donor | 0.389 | |
| FAT4 | rs1014867 | Exon 17 | Missense Pro4972Ser Esophageal cancer risk26 |
0.59 |
| rs1039808 | Exon 1 | Missense Ala807Val Esophageal cancer risk26 |
NFI | |
| RASSF1 | rs2073498 | Exon 3 | Missense Ala133Ser Breats cancer risk28 |
0.5 |
| rs2236947 | Intron | Transcriptional regulation | 0.268 |
Abbreviations: MST1: STE20-like kinase 1; MST2: STE20-like kinase 2; LATS1: large tumor suppressor 1; LATS2: large tumor suppressor 2; YAP1: yes associated protein; TAZ: transcriptional co-activator with PDZ-binding motif; FAT4: atypical cadherin 4; RASSF1: Ras-association domain 1; NA: not analyzed; NFI: no functional information; NSCLC: non small cell lung cancer.