Table 3.

Overview of the image analysis methodologies reported in clinical studies employing the RFI device.

Authors [ref.]	FOV reported (Y/N)	FOV (20°/35°/NA)	VSL reported (Y/N)	S/L/Mixed segments	A/V crossings marked (Y/N)	Most vessels marked (Y/N)	Pathology studied
Arbel et al. [23]	N	20°	N	Long (mixed)	N	Y	Slow coronary flow (n=28)
Barak et al. [11]	N	20°	N	Long (mixed)	N/A	N	wet AMD after Avastin (n=8)
Beutelspacher et al. [13]	N	35°	N	Mixed	N	Y	Central Serous Chorioiretinopathy (n=12)
Birger et al. [15]	N	20°	N	Mixed	N	N	severe hyperlipidemia (n=1)
Burgansky-Eliash et al. [9]	Y	20°	N	Mixed	N	Y	NPDR (n=58 NPDR / 51 Healthy)
Burgonsky-Eliash et al. [12]	N	20°	N	Long (mixed)	N	N	wet AMD (n=63 wet AMD / n=53 Healthy)
Burgonsky-Eliash et al. [10]	N	20°	Y	Short	N	Y	Physiological parameters in healthy (n=67)
Chablani et al. [27]	Y	35°	Y	Short	Y	N	Reproducibility (n=18)
Gutfreund et al. [18]	N	20°	N	Long (mixed)	N	Y	Metabolic syndrome (n=20 MetS / 21 Healthy)
Izhaky et al. [19]	N	20°	N	Mixed	N/A	Y	review with an image
Landa and Rosen [14]	Y	35°	N	N/A	N/A	N/A	Idiopathic Juxtafoveal Teleangiectasia (n=10)
Landa Jangi et al. [24]	Y	20	N	Long (mixed)	N	Y	Healthy subjects (n=27 subj/54 eyes)
Landa et al. [20]	N	N/A	N/A	N/A	N/A	N/A	DME (n=39)
Landa et al. [8]	N	35°	N	Mixed	Y	Y	Various (n=17 of 14 subjects)

Please note that in cases where the Field of View (FOV) was not reported, it was described by the figure(s) published in the given study. Y: yes, N: no; N/A: not available, VSL: vessel segment length, S: short segments (<100 pixels or <400μm), L: long segments (100-200 pixels or 400-800μm), “Long (mixed)”: mostly long segments with some short segments visible in the illustration shown in the reference. A/V crossing: arterio-venous crossing, AMD: age-related macular degeneration, NPDR: non-proliferative diabetic retinopathy, DME: diabetic macular edema.