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. 2016 Mar 15;5:12. doi: 10.1186/s40169-016-0088-3

Fig. 2.

Fig. 2

Formation of estrogens, catechol estrogen metabolic pathway and DNA adducts of estrogens. Activating enzymes and depurinating DNA adducts are in red and protective enzymes are in green. N-acetylcysteine (NAC, shown in blue) and resveratrol (Res, shown in burgundy) indicate the various steps where NAC and Res can improve unbalanced estrogen metabolism by reducing formation of depurinating estrogen-DNA adducts