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. 2016 Mar 16;36(11):3106–3114. doi: 10.1523/JNEUROSCI.1327-15.2016

Figure 4.

Figure 4.

METH-induced decrease in IBaclofen requires activation of D1-like and D2-like receptors. A, Protocols for examining the effect of D1R-like or D2R-like receptor antagonists coinjected with METH or saline in Pitx3+/−-GFP mice. B, Mean IBaclofen (300 μm) is reduced in VTA DA neurons 24–48 h after 5 d injections of METH (2 mg/kg) compared with saline (0.9%). Coinjection of METH with the D1R-like antagonist SCH39166 (0.3 mg/kg) or METH with the D2R-like antagonist eticlopride (0.1 mg/kg) prevents METH-dependent decrease in IBaclofen (**p < 0.01 two-way ANOVA with Bonferroni post hoc test.).