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. 2016 Mar 16;36(11):3106–3114. doi: 10.1523/JNEUROSCI.1327-15.2016

Figure 6.

Figure 6.

Requirement for the GIRK3 subunit in METH-dependent decrease in IBaclofen. A, Protocol shown for GIRK3 KO mice: 5 d injections of METH or saline. Examples of IBaclofen (300 μm) recorded from VTA DA neurons 24–48 h after 5 d intraperitoneal injections of saline (0.9%) or METH (2 mg/kg) in GIRK3 KO mice. B, No significant decrement in mean IBaclofen in VTA DA neurons from GIRK3 KO mice receiving 5 d METH injection (n = 13) compared with 5 d saline injection mice (n = 9) (ns, p > 0.05 unpaired t test). C, Ih in VTA DA neurons after 5 d METH or 5 d saline in GIRK3 KO mice.