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. 2016 Mar 16;36(11):3309–3321. doi: 10.1523/JNEUROSCI.0257-15.2016

Figure 6.

Figure 6.

JNK inhibition, but not ERK inhibition, blocks GPER-mediated cell signaling in the DH. A, B, Intracerebroventricular infusion of 8 ng G-1 increased phosphorylation of p46 JNK (A) and p54 JNK (B) relative to vehicle 5 min later. These effects were blocked by DH SP600125 infusion (n = 7/group). C, Neither G-1 nor SP600125 altered ERK phosphorylation (n = 7/group). D, E, The increase in p46 (D) and p54 (E) phosphorylation induced by intracerebroventricular infusion of 8 ng G-1 was not blocked by DH U0126 infusion (n = 6/group). F, Neither G-1 nor the behaviorally subeffective dose of U0126 altered ERK phosphorylation (n = 6/group). Each bar represents the mean ± SEM percentage change from vehicle (*p < 0.05, **p < 0.01). Insets, Representative Western blots.