Figure 10.

dmPFC neuronal encoding of the task rule, examined specifically in conflict trials. a, The spike raster plots of example dmPFC units that discriminatively represented side (conflict) and light trials during the preaction period. Format same as spike raster plots above. b, Bar plot represents the proportion of dmPFC rule-encoding units in side CF (vehicle, 21 units; 5 mg/kg, 18 units; 10 mg/kg, 9 units) and light CF (vehicle, 13 units; 5 mg/kg, 12 units; 10 mg/kg, 9 units) trials during the preaction period. The proportion of rule-encoding units in side CF trials decreased in a dose-dependent manner. ^#Significantly different proportion of encoding units compared with that of the vehicle units. c, The neural discriminability of light CF or side CF trials, relative to the trials of the other rule, was quantified using an ROC analysis. Each line segment represents an individual rule-encoding unit's ROC value for the light CF trials (left filled circle) and the side CF trials (right filled circle).