Figure 2.

Modulation of set-shifting task performance by FG7142. a, Top left, Example correct performance in the light rule, where a nose poke to the illuminated port is rewarded. Bottom left, Light rule trials were subtyped to conflict or nonconflict trials, based on correspondence between illuminated and previously valid side indicated with dotted arrows. Top right, Example correct performance in the side rule, where a nose poke to the valid side (e.g., the left port) is rewarded, regardless of illumination. Bottom right, Side rule trials were subtyped to conflict or nonconflict trials, based on correspondence between illuminated and valid side indicated with solid arrows. b, The number of total trials and total time to complete the task were equivalent across dose groups. Each circle represents an individual data point. Horizontal bar represents the mean of each dose group. c, The number of trials to reach the set-shifting criterion (10 consecutive correct trials) in light and side rule sets was displayed for each dose group. d, The number of errors in light and side rule sets was displayed for each dose group. *Significant difference in the number of trials to the criterion or errors between light and side rule sets. e, Distinct choice accuracy was observed in different trial types. All rats were more prone to errors in conflict trials. Such error propensity was more pronounced under the side rule, especially in the 10 mg/kg treated rats. *Significant difference compared with the vehicle-treated rats. f, The RT from the cue onset to the action trended toward a dose-dependent increase in all trial types.