Figure 3.

dmPFC periaction neuronal activity during the set-shifting task. a–c, The baseline-normalized periaction activity of vehicle- or FG7142-treated units with the action occurring at time = 0, aligned to the time of the nose poke detected by the beam break at the cue port. dmPFC units tended to start modulating their activity preceding the action. The number of units (n) and rats (N): vehicle, n = 63, N = 8; 5 mg/kg, n = 67, N = 8; 10 mg/kg, n = 61, N = 7. d, The mean baseline firing rates of FG7142-injected units, measured during intertrial intervals, were significantly lower than vehicle units, consistent with the effect observed in home cage recording. Error bars indicate SE. *Statistically significant difference compared with vehicle. e, Left, The normalized population activity during the periaction period is displayed as mean ± SE (shaded area). Right, The mean population activity within the 2 s preaction period. f, The percentages of units classified as “Activated” in preaction and postaction periods were not significantly different across dose groups. Few units were classified as “Inhibited.”