Figure 4.

OFC periaction neuronal activity during the set-shifting task. a–c, The baseline-normalized periaction activity of vehicle- or FG7142-treated units with the action occurring at time = 0. OFC units tended to modulate their activity during the postaction period. The number of units (n) and rats (N): vehicle, n = 34, N = 5; 5 mg/kg, n = 29, N = 5; 10 mg/kg, n = 24, N = 4. d, The mean baseline firing rate of FG7142-exposed units was numerically lower than vehicle units, consistent with the effect observed during home cage recording. Error bars indicate SE. e, Left, The normalized population activity during the postaction period is displayed as mean ± SE (shaded area). Right, The mean population activity within the 2 s postaction period. f, The percentages of units classified as “Activated” in preaction and postaction periods did not significantly differ across dose groups. Few units were classified as “Inhibited.”