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. 2016 Mar 10;7:10975. doi: 10.1038/ncomms10975

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A schematic of the regulation of APC/C–Cdc20 activity in interphase by cyclin A2–Cdk2 phosphorylation of Cdc20. On mitotic entry, cyclin A2 is degraded and the SAC inhibits APC/C–Cdc20 instead. The black line indicates the hypothetical strength of APC/C–Cdc20 activity during the cell cycle.