Table 2.

The influence of FLG mutations, IL-18 and IL-13 genotypes and alleles on the AD risk

Variable	P-value	OR	–95% CL	+95% CL
2282del4 FLG mutation	0.01	2.35	4.519	1.223
R501X FLG mutation	0.39	0.684	0.289	1.616
2282del4 or R501X FLG mutations	0.016	1.885	3.179	1.118
IL-18	< 0.0001	2.672	3.861	1.849
GG genotype of IL-18	< 0.0001	5.412	2.761	10.608
G-allele of IL-18	0.000029	5.351	2.429	11.804
C-allele of IL-18	< 0.0001	0.308	0.508	0.178
–1112 C/T IL-13	0.013	2.021	1.159	3.526
T-allele of IL-13	0.001	2.319	3.940	1.365
C-allele of Il-13	0.038	0.111	0.014	0.892
2282del4 or R501X mutation and GG genotype of IL-18	0.00013	5.815	2.342	14.439
2282del4 or R501X mutation and T-allele of IL-13	0.12	0.625	0.348	1.123