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. 2015 Oct 7;41(5):1210–1222. doi: 10.1038/npp.2015.268

Figure 1.

Figure 1

Rewarding effects of cocaine in conditional 5-HT1A autoKD mice. (a) Scheme of the cocaine-induced conditioned place preference (CPP) test. Effects of 7.5 mg/kg cocaine on CPP in wild-type mice (b), 5-HT1A autoKD mice (c), tTS− DOX-ON mice (d), and tTS− DOX-OFF mice (e). **P<0.01, CS− of post-test vs CS+ of post-test. 5-HT1A autoKD, 5-HT1A autoreceptor knockdown; CS, conditioned stimulus (cocaine); DOX-OFF, mice fed regular chow; DOX-ON, mice fed doxycycline chow; tTS, tetracycline-dependent transcriptional suppressor.