Figure 4.
5-HT1A autoreceptor inhibition attenuated the heightened motivation for cocaine self-administration in a rat model of cocaine addiction. (a) Scheme of testing the effect of WAY100635, a 5-HT1A receptor antagonist, on cocaine self-administration under PR. (b) Entire-session cocaine self-administration with short access (ShA) and extended access (LgA) in rats that were tested with systemic injection of WAY100635. *P<0.05, ***P<0.001, compared with session 1. (c) The first hour of cocaine self-administration in ShA and LgA rats that received a systemic injection of WAY100635. *P<0.05, ***P<0.001, compared with session 1. (d) Systemic injection effect of various doses of WAY100,635 on cocaine self-administration under a PR schedule. *P<0.05, ***P<0.001, compared with 0.5X phosphate-buffered saline (PBS; zero dose); #P<0.05, compared with ShA group. (e) Intradorsal raphe infusion effect of WAY100,635 on cocaine self-administration under a PR schedule. **P<0.01, compared with zero dose.