Table 1. Participant Characteristics.
| Oxytocin (n=24) | Placebo (n=20) | Statistics | |
|---|---|---|---|
| N—included in fMRI analyses | 19 | 18 | |
| Males (n (%)) | 9 (37.5%) | 9 (45%) | χ2=0.25, df=1, p=0.61 |
| Age (years) | 29.5 (11.4) | 32.3 (11.5) | t42=−0.82, p=0.42 |
| Current smoker (n (%)) | 1 (4%) | 3 (15%) | χ2=1.55, df=1, p=0.21 |
| Type of trauma | χ2=2.31, df=3, p=0.51 | ||
| Motor vehicle traffic accident (n (%)) | 12 (50%) | 14 (70%) | |
| Accident at work/home (n (%)) | 5 (21%) | 3 (15%) | |
| Interpersonal trauma (n (%)) | 6 (25%) | 3 (15%) | |
| Other (n (%)) | 1 (4%) | 0 (0%) | |
| Childhood trauma (ETI total) | 5.2 (4.4) | 5.2 (3.6) | t42=−0.11, p=0.92 |
| Days between trauma and scan session | 8.8 (1.3) | 8.0 (2.8) | t42=−0.30, p=0.77 |
| MINI lifetime PTSD (n (%)) | 6 (26.1%) | 1 (5%) | χ2=3.49, df=1, p=0.06 |
| MINI lifetime MDD (n (%)) | 6 (25%) | 6 (30%) | χ2=0.14, df=1, p=0.71 |
| MINI lifetime alcohol/substance dependence (n (%)) | 1 (4.2%) | 1 (5.0%) | χ2=0.02, df=1, p=0.90 |
| MINI lifetime psychotic disorder (n (%)) | 0 (0%) | 0 (0%) | NA |
| MINI lifetime bipolar disorder (n (%)) | 1 (4.2%) | 1 (5%) | χ2=0.02, df=1, p=0.90 |
| CAPS total | 45.1 (21.2) | 39.1 (16.9) | t42=1.02, p=0.32 |
| CAPS re-experiencing | 19.2 (9.9) | 13.5 (7.9) | t42=2.09, p=0.04 |
| CAPS avoidance | 9.9 (7.7) | 10.8 (5.3) | t42=−0.43, p=0.67 |
| CAPS hyperarousal | 16.0 (8.1) | 14.9 (8.0) | t42=0.47, p=0.64 |
Abbreviations: CAPS, Clinical Administered PTSD Scale; ETI, Early Trauma Inventory; fMRI, functional magnetic resonance imaging.
Demographic and clinical variables (±SD) for the oxytocin and placebo group assessed at the pre-intervention appointment. Statistically significant group differences (p<0.05) are in boldface.