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. 2015 Oct 21;41(5):1308–1318. doi: 10.1038/npp.2015.280

Figure 5.

Figure 5

Blockade of CB1 receptors mimics the effects of FR on glutamate release, LTP formation and BDNF expression in the hippocampus of non-FR rats. Control non-FR rats were treated either with SR141716 (1 mg/kg, i.p.) or vehicle for 7 days. (a) Representative traces showing paired fEPSPs from both experimental groups (scale bars: 0.5 mV, 10 ms). (b) Bar graph showing the PP ratio values for fEPSP slope obtained from vehicle and SR141716-treated rats (n=6). (c) Changes in fEPSP slope induced by HFS relative to baseline and, above, representative fEPSPs recorded before and 1 h after HFS (black arrow; scale bars: 0.5 mV, 5 ms). (d) Bar graph of the averaged fEPSP slope values obtained during the last 10 min of LTP recording, compared with the relative baseline (n=6). (e, f) Representative blot as well as quantitative analysis of the BDNF/GAPDH ratio in hippocampal protein extracts (n=5). *P<0.05; ***P<0.001 vs vehicle-treated rats, Student's t-test. BDNF, brain-derived neurotrophic factor; fEPSP, field excitatory postsynaptic potential; FR, food restriction; LTP, long-term potentiation.