Table 3. Impact of Treatment on Depressive Symptoms and Post-concussive Symptoms.

	GAL vs Placebo	MPH vs Placebo
Summary of Patient Health Questionnaire−9 (PHQ9): change from baseline MMRM analysis
Week 4
LS mean change	−3.2805	−5.7523
SEM	1.8977	2.0842
CI lower limit	−7.0000	−9.8374
CI upper limit	0.4390	−1.6673
p-value	0.0886	0.0075
Week 8
LS mean change	−1.8700	−4.1254
SEM	1.3475	1.4877
CI lower limit	−4.5110	−7.0413
CI upper limit	0.7710	−1.2095
p-value	0.1699	0.0072
Week 12
LS mean change	−3.9102	−5.6124
SEM	1.4752	1.6158
CI lower limit	−6.8016	−8.7793
CI upper limit	−1.0188	−2.4455
p-value	0.0101	0.0009
Summary of Rivermead Postconcussion Symptom Questionnaire (RPQ13): change from baseline MMRM analysis
Week 4
LS mean change	−5.3061	−9.6851
SEM	4.5370	4.7382
CI lower limit	−14.1985	−18.9719
CI upper limit	3.5863	−0.3983
p-value	0.2482	0.0467
Week 8
LS mean change	−7.3752	−13.7272
SEM	4.9482	5.1607
CI lower limit	−17.0735	−23.8421
CI upper limit	2.3231	−3.6123
p-value	0.1429	0.0107
Week 12
LS mean change	−6.7202	−12.0600
SEM	4.1718	4.3327
CI lower limit	−14.8968	−20.5520
CI upper limit	1.4564	−3.5681
p-value	0.1141	0.0078