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. 2015 Oct 21;41(5):1199–1209. doi: 10.1038/npp.2015.297

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Copyright © 2016 American College of Neuropsychopharmacology

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Ghrelin increases impulsive action measured in the go/no-go task. Centrally injected ghrelin increased the number of rewards earned (a) and the number of active lever presses (b) during the go periods of the go/no-go task, indicating that ghrelin increases the motivation to obtain food rewards. However, ghrelin also increased the number of active lever presses during the no-go period (c), potentially indicating an inability to withhold a response despite the no-go cue. Ghrelin had no effect on the number of responses emitted on the inactive lever (d), which supports lack of changes in general motor activity. Number of sucrose pellets earned during the no-go trials (e). Data are expressed as mean±SEM. n=9 per each treatment group. *p<0.05.