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. 2015 Oct 21;41(5):1199–1209. doi: 10.1038/npp.2015.297

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Copyright © 2016 American College of Neuropsychopharmacology

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Ghrelin increases impulsive choice measured in the delay discounting task. Ghrelin treatment increased the amount of large rewards obtained when offered with no delay but reduced the amount of large food rewards earned when offered under 10- or 20-s delay (a). The impulsive behavior resulted in a loss of rewards earned during the 10- and 20-s delays but not when there was no delay imposed on the large rewards (b). No significant changes in locomotor activity were detected after ghrelin treatment during the delay discounting task (c). Data are expressed as mean±SEM. n=25–26 per each treatment group. *p<0.05, **p<0.005, ***p<0.0005.