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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: J Immunol. 2015 Nov 20;196(1):29–33. doi: 10.4049/jimmunol.1501048

Figure 2.

Figure 2

DNA in the lung is protective to IAV infection.

(A) Schematic for transduced expression of DNaseI. (B) dnase1 mRNA measured by qPCR with total RNA isolated from lungs of AAV-GFP and AAV-DNaseI treated mice. (C) DNA in cell-depleted BAL fluid in uninfected controls compared to AAV-GFP and AAV-DNaseI treated mice at 5 dpi with PR8. (D) Survival comparison between AAV-GFP and AAV-DNaseI treated WT mice challenged with 4 ×104 pfu PR8. Data combined from two independent experiments (AAV-GFP, n = 17; AAV-DNaseI, n = 15). (E) Viral titers of lung homogenates from AAV-GFP and AAV-DNaseI treated mice at 3, 6, and 9 dpi with PR8. (F–H)) Total number of CD45+ leukocytes (F), CD4+ T cells (G), and CD8+ T cells (H) in the total lungs of AAV-GFP and AAV-DNaseI treated mice at 5 dpi with PR8. *, P 0.05