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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: J Immunol. 2015 Nov 20;196(1):29–33. doi: 10.4049/jimmunol.1501048

Figure 3.

Figure 3

AIM2 is protective during IAV infection.

(A) Survival comparison of WT and Aim2−/− mice infected with 4 ×104 pfu PR8 (WT, n=6; Aim2−/−, n=5). (B) Viral titers of lung homogenates from WT and Aim2−/− at 3, 6, and 9 dpi with PR8. (C–F) Levels of IL-1β (D), IL-6 (E), and TNFα (F) protein in lung homogenates at 3 and 5 dpi.(G) Concentration of serum albumin in BAL washings of WT and Aim2−/− at 3 dpi. (G) Survival comparison of lethally irradiated WT mice engrafted with WT and Aim2−/− bone marrow infected with PR8 (WT>WT, n=10; Aim2−/−>WT, n=9)