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. 2016 Mar 16;6:22375. doi: 10.1038/srep22375

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Copyright © 2016, Macmillan Publishers Limited

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(a) Linearity of 8-oxo-dG/[¹³C¹⁵N₂]8-oxo-dG at constant [¹³C¹⁵N₂]8-oxo-dG amount (10 fmol on-column) and 8-oxo-dG ranging from 0.1 to 4 fmol (on-column). (b) Linearity of 8-oxo-dA/[¹³C₂¹⁵N]8-oxo-dA at constant [¹³C₂¹⁵N]8-oxo-dA amount (10 fmol on-column) and 8-oxo-dA ranging from 0.02 to 4 fmol (on-column). (c) Correlation between added and measured amounts of 8-oxo-dG. Various amounts of 8-oxo-dG (1, 2.5, 5, 10 fmol) were added to CT-DNA (50 ng), and analyzed by the developed method; 8-oxo-dG present in the CT-DNA was subtracted from each value. (d) Correlation between added and measured amounts of 8-oxo-dA. Various amounts of 8-oxo-dA (0.25, 1, 5, 10 fmol) were added to CT-DNA (50 ng), and analyzed by the developed method.