Figure 3. C9orf72^−/− mice show increased expression of T cell activation markers by FACS analysis.

(A) CD8⁺ T cell summary data reflect increases in the percentage of CD8 T cells expressing the activation markers CD44 and CD69 and the co-inhibitory receptor PD-1 in C9orf72^−/− compared with WT. (B) Similarly, CD4⁺ T cell summary data represent increased percentages of C9orf72^−/− CD4 T cells expressing CD44, CD69, and PD1 in spleen, cervical LN, and kidney with varying significance. Graphs represent mean ± s.e.m. (*P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001 by unpaired Students t-test) 30–35 week females, n = 4 per genotype.