Table 3. Flunixin pharmacokinetic parameters following oral administration through 800 g of pelleted feed to eight sheep at a dose rate of 4 mg/kg.
| Parameter (units) | Sheep ID | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 305 | 466 | 580 | 612 | 621 | 627 | 648 | 732 | Mean ± S.D. | |
| t1∕2, h | 4.59 | 5.39 | 8.23 | 6.29 | 7.31 | 4.85 | 11.04 | 5.19 | 7.95 ± 2.19 |
| Tmax, h | 8.00 | 1.00 | 6.00 | 6.00 | 2.00 | 12.00 | 12.00 | 4.00 | 6.00 ± 4.14 |
| Cmax, μg/mL | 2.39 | 1.61 | 2.18 | 1.89 | 2.16 | 1.33 | 1.63 | 2.80 | 1.78 ± 0.48 |
| AUC0-t, μg/mL*h | 29.96 | 38.00 | 38.21 | 40.99 | 42.78 | 31.84 | 42.75 | 36.05 | 37.68 ± 4.77 |
| MRT, h | 9.36 | 14.34 | 13.36 | 13.43 | 12.98 | 15.80 | 19.48 | 9.32 | 13.59 ± 3.31 |
Notes.
a
Flunixin non-compartmental pharmacokinetics (PK Solver; China Pharmaceutical University, Nanjing, Jiangsu, China) (Zang et al., 2010).
- t1∕2
- elimination half-life
- Cmax
- the maximum flunixin concentration in plasma
- Tmax
- the time required to reach Cmax
- AUC0-t
- area under the concentration vs. time curve
- MRT
- mean residence time