Table 1. Gene Ontology enrichments of clusters.
| Cluster | GO-term | FDR corrected P-valuea |
|---|---|---|
| Rumen | EDC locusb | 7.1E-13c |
| Epithelia-rumen-tonsil | EDC locusb | 8.6E-15c |
| Defense response to fungus | 8.6E-03 | |
| Epithelia-rumen bias | Keratinization | 2.4E-04 |
| Epithelia-all | – | – |
| Epithelia-large intestine | Desmosome organization | 4.7E-03 |
| Epithelia-GI-liver | Cell junction organization | 6.3E-03 |
| Abomasum-intestine | – | – |
| Intestine-low in rectum | – | – |
| Large intestine | Regulation of chloride transport | 4.5E-05 |
| Intestine | – | – |
| Epithelia-intestine | Cell cycle process | 1.4E-46 |
| Abomasum | Digestion | 3.8E-02 |
| Small intestine | – | – |
| Rumen-abomasum | Platelet aggregation | 2.2E–04 |
| Rumen-intestine-liver | Flavonoid biosynthetic process | 5.5E–10 |
| Intestine-spleen | Humoral immune response | 4.5E–02 |
Notes.
a
Top significantly enriched pathway selected from GOrilla analysis (see ‘Methods’) for each input gene cluster.
b
Genes in the EDC locus of the sheep genome.
c
Enrichment of EDC locus genes was calculated using the hypergeometric distribution.