Table 2. Key proteins of the miRNA biogenesis with their structural domains.
Process step | Protein name | Domains |
---|---|---|
Microprocessor complex | DROSHA | 2× RIBO III + 1× DSRM |
DGCR8 | 1× WW + 2× DSRM | |
Moving to cytoplasm | XPO5 | 1× XPO1 |
RAN | 1× RAN | |
RISC loading complex | DICER | PDB + Helicase + DICER + PAZ + 2× RIBO + DSRM |
TARBP2 | 3× DSRM | |
Final miRNA maturation | AGO | DUF + PAZ + PIWI |
PIWI-like | PAZ + PIWI |