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. 2016 Mar 16;14:19. doi: 10.1186/s12915-016-0242-9

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© Li et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Mesodermal progenitor-specific deletion of Alk5 reduced the sub-mesothelial mesenchyme. (a–f) Gross morphology (a, d, b, and e) and hematoxylin and eosin staining (c and f) show decreased sub-mesothelial mesenchyme in Alk5 ^Dermo1 mutant lungs at E12.5 (b, e, c, and f) or E13.5 (a and d). (g) Quantitative PCR showed decreased Fgf 7, Fgf9, and Fgf10 mRNA in E13.5 Alk5 ^Dermo1 lungs; n = 2 controls and 3 mutant lungs. (h) Western blot analysis showed decreased FGF signaling target genes. β-ACTIN was used as control, n = 3. Error bars show standard deviation. Scale bar: f = 20 μm