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Chronology of the embryonic blood–brain barrier transport system formation
| Morphological or physiological aspect | Embryonic day (E) | |
|---|---|---|
| Chick | Rat | |
| Closure of anterior neuropore/initial differentiation of eCSF protein content | E1.7−E2 | E10.5−E11 |
| Brain cavity becomes physiologically sealed | E3.5−E4 | E12.4−E12.7 |
| Transient embryonic blood–brain barrier starts to be physiologically functional | A bit before E4 | A bit before E12.7 |
