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. Author manuscript; available in PMC: 2016 Mar 16.
Published in final edited form as: Cell Signal. 2012 Apr 13;24(8):1592–1598. doi: 10.1016/j.cellsig.2012.04.004

Fig. 6.

Fig. 6

Model of disruption of eag domain interaction with the channel by LQT2 mutations. A. An eag domain mutation which disrupts slow deactivation gating also interferes with the interaction of the eag domain with the channel. B. A genetically encoded eag domain fragment is able to replace the mutated domain and modulate channel gating.