Fig. 7.

Cyclic nucleotide-binding homology domain residues involved in LQT2 and gating. A. CPK model of the CNBHD viewed looking down from the plasma membrane. B. CNBHD model from A rotated 90° to show a side view. C. CNBHD model from A rotated 180° to show the cytoplasmic face. Red residues are hydrophobic residues which have been shown to speed channel deactivation gating, blue residues are identified LQT2 mutation sites that have been shown to speed deactivation gating, and yellow residues are all others which have been shown to speed deactivation gating. Images were created using PyMOL (based on Zagotta et al.; PDB ID:1Q5O) [17].